Write a following code in page load event:-
if (!IsPostBack)
{
SqlConnection cnn = new SqlConnection("Write SQL connection string");
SqlCommand cmd = new SqlCommand("write SQL command ", cnn);
SqlDataAdapter da = new SqlDataAdapter(cmd);
DataSet ds = new DataSet();
da.Fill(ds);
DropDownList1.AppendDataBoundItems = true;
DropDownList1.Items.Add(new ListItem { Text = "---please select--", Value ="0" });
DropDownList1.DataSource = ds;
DropDownList1.DataTextField = "appt database coloum name";
DropDownList1.DataBind();
}