Unable to evaluate expression because the code is optimized or a native frame is on top of the call stack

I want to export the data to pdf in which table has 150 columns. 

When i save the file in directory , the file is opening. whereas when open it directly some box type is displaying. 

And also am getting exception in Response.End() method which is given below

"Unable to evaluate expression because the code is optimized or a native frame is on top of the call stack."