Here I have created sample that will help you out.
HTML
<div>
<asp:Label ID="lblMessage" runat="server" Text="AspSnippets.com" />
</div>
C#
protected void Page_Load(object sender, EventArgs e)
{
PrivateFontCollection pfc = new PrivateFontCollection();
pfc.AddFontFile(@"C:\Users\shashikant\Desktop\ALGER.ttf");
lblMessage.Font.Name = pfc.Families[0].Name;
}
VB
Protected Sub Page_Load(sender As Object, e As System.EventArgs) Handles Me.Load
Dim pfc As New PrivateFontCollection()
pfc.AddFontFile("C:\Users\shashikant\Desktop\ALGER.ttf")
lblMessage.Font.Name = pfc.Families(0).Name
End Sub
Output
AspSnippets.com