Hi indradeo,
Ues the GridView OnRowDataBound event handler and loop through each cell in the row. Then replace the Invalid value with blank in each cell.
Refer below example.
HTML
<asp:GridView runat="server" ID="GridView1" AutoGenerateColumns="false"
    OnDataBound="OnDataBound" OnRowDataBound="OnRowDataBound">
    <Columns>
        <asp:BoundField DataField="Parameters" HeaderText="Parameters" />
        <asp:BoundField DataField="PM10" HeaderText="PM10" />
        <asp:BoundField DataField="PM2.5" HeaderText="PM2.5" />
        <asp:BoundField DataField="SO2" HeaderText="SO2" />
        <asp:BoundField DataField="NO" HeaderText="NO" />
        <asp:BoundField DataField="NO2" HeaderText="NO2" />
        <asp:BoundField DataField="NOx" HeaderText="NOx" />
        <asp:BoundField DataField="CO2" HeaderText="CO2" />
    </Columns>
</asp:GridView>
Namespaces
C#
using System.Data;
using System.Drawing;
VB.Net
Imports System.Data
Imports System.Drawing
Code
C#
protected void Page_Load(object sender, EventArgs e)
{
    if (!this.IsPostBack)
    {
        DataTable dt = new DataTable();
        dt.Columns.AddRange(new DataColumn[] {
            new DataColumn("Parameters", typeof(string)),
            new DataColumn("PM10", typeof(string)),
            new DataColumn("PM2.5",typeof(string)),
            new DataColumn("SO2", typeof(string)),
            new DataColumn("NO", typeof(string)),
            new DataColumn("NO2", typeof(string)),
            new DataColumn("NOx", typeof(string)),
            new DataColumn("CO2", typeof(string))
        });
        dt.Rows.Add("2023-12-28 15:00:00+00:00", "9.26", "3.79", "Invalid", "20.67", "Invalid", "42.58", "Invalid");
        dt.Rows.Add("AVG DATA", "9.33", "Invalid", "9.26", "9.26", "21.43", "42.01", "20.67");
        dt.Rows.Add("MAX DATA", "Invalid", "3.90", "Invalid", "Invalid", "19.93", "44.30", "Invalid");
        dt.Rows.Add("MIN DATA", "9.26", "Invalid", "3.90", "9.45", "Invalid", "39.80", "Invalid");
        GridView1.DataSource = dt;
        GridView1.DataBind();
    }
}
protected void OnDataBound(object sender, EventArgs e)
{
    GridViewRow row = new GridViewRow(0, 0, DataControlRowType.Header, DataControlRowState.Normal);
    TableHeaderCell cell = new TableHeaderCell();
    cell.Text = "UoM";
    cell.ColumnSpan = 1;
    row.Controls.Add(cell);
    cell = new TableHeaderCell();
    cell.ColumnSpan = 1;
    cell.Text = "µg/m3";
    row.Controls.Add(cell);
    cell = new TableHeaderCell();
    cell.ColumnSpan = 1;
    cell.Text = "µg/m3";
    row.Controls.Add(cell);
    cell = new TableHeaderCell();
    cell.ColumnSpan = 1;
    cell.Text = "µg/m3";
    row.Controls.Add(cell);
    cell = new TableHeaderCell();
    cell.ColumnSpan = 1;
    cell.Text = "µg/m3";
    row.Controls.Add(cell);
    cell = new TableHeaderCell();
    cell.ColumnSpan = 1;
    cell.Text = "µg/m3";
    row.Controls.Add(cell);
    cell = new TableHeaderCell();
    cell.ColumnSpan = 1;
    cell.Text = "µg/m3";
    row.Controls.Add(cell);
    cell = new TableHeaderCell();
    cell.ColumnSpan = 1;
    cell.Text = "µg/m3";
    row.Controls.Add(cell);
    row.BackColor = ColorTranslator.FromHtml("#3AC0F2");
    GridView1.HeaderRow.Parent.Controls.AddAt(0, row);
}
protected void OnRowDataBound(object sender, GridViewRowEventArgs e)
{
    if (e.Row.RowType==DataControlRowType.DataRow)
    {
        foreach (TableCell cell in e.Row.Cells)
        {
            if (cell.Text.ToLower()== "invalid")
            {
                cell.Text = string.Empty;
            }
        }
    }
}
VB.Net
Protected Sub Page_Load(ByVal sender As Object, ByVal e As EventArgs) Handles Me.Load
    If Not Me.IsPostBack Then
        Dim dt As DataTable = New DataTable()
        dt.Columns.AddRange(New DataColumn() {
                            New DataColumn("Parameters", GetType(String)),
                            New DataColumn("PM10", GetType(String)),
                            New DataColumn("PM2.5", GetType(String)),
                            New DataColumn("SO2", GetType(String)),
                            New DataColumn("NO", GetType(String)),
                            New DataColumn("NO2", GetType(String)),
                            New DataColumn("NOx", GetType(String)),
                            New DataColumn("CO2", GetType(String))})
        dt.Rows.Add("2023-12-28 15:00:00+00:00", "9.26", "3.79", "Invalid", "20.67", "Invalid", "42.58", "Invalid")
        dt.Rows.Add("AVG DATA", "9.33", "Invalid", "9.26", "9.26", "21.43", "42.01", "20.67")
        dt.Rows.Add("MAX DATA", "Invalid", "3.90", "Invalid", "Invalid", "19.93", "44.30", "Invalid")
        dt.Rows.Add("MIN DATA", "9.26", "Invalid", "3.90", "9.45", "Invalid", "39.80", "Invalid")
        GridView1.DataSource = dt
        GridView1.DataBind()
    End If
End Sub
Protected Sub OnDataBound(ByVal sender As Object, ByVal e As EventArgs)
    Dim row As GridViewRow = New GridViewRow(0, 0, DataControlRowType.Header, DataControlRowState.Normal)
    Dim cell As TableHeaderCell = New TableHeaderCell()
    cell.Text = "UoM"
    cell.ColumnSpan = 1
    row.Controls.Add(cell)
    cell = New TableHeaderCell()
    cell.ColumnSpan = 1
    cell.Text = "µg/m3"
    row.Controls.Add(cell)
    cell = New TableHeaderCell()
    cell.ColumnSpan = 1
    cell.Text = "µg/m3"
    row.Controls.Add(cell)
    cell = New TableHeaderCell()
    cell.ColumnSpan = 1
    cell.Text = "µg/m3"
    row.Controls.Add(cell)
    cell = New TableHeaderCell()
    cell.ColumnSpan = 1
    cell.Text = "µg/m3"
    row.Controls.Add(cell)
    cell = New TableHeaderCell()
    cell.ColumnSpan = 1
    cell.Text = "µg/m3"
    row.Controls.Add(cell)
    cell = New TableHeaderCell()
    cell.ColumnSpan = 1
    cell.Text = "µg/m3"
    row.Controls.Add(cell)
    cell = New TableHeaderCell()
    cell.ColumnSpan = 1
    cell.Text = "µg/m3"
    row.Controls.Add(cell)
    row.BackColor = ColorTranslator.FromHtml("#3AC0F2")
    GridView1.HeaderRow.Parent.Controls.AddAt(0, row)
End Sub
Protected Sub OnRowDataBound(ByVal sender As Object, ByVal e As GridViewRowEventArgs)
    If e.Row.RowType = DataControlRowType.DataRow Then
        For Each cell As TableCell In e.Row.Cells
            If cell.Text.ToLower() = "invalid" Then
                cell.Text = String.Empty
            End If
        Next
    End If
End Sub
Screenshot
