Separate out and search comma separated values in Database columns in SQL Server

Hi

i have one table in sql server called student_info

in this table keyskills column contain value like below

'c,c++c#'

'c++,c,c#'

'c,c++,c#,asp.net'

etc

i want to search the student information based on keyskills like naukri

1.Any keyskills from textbox1

2.All keyskills from textbox2

3.Except keyskills from textbox3

when i enter c,c++ or c++,c in textbox1 then it will dispaly all the student whose have c,c++ keyskill

how to achieve this.