Are you using Ajax Control toolkit Combobox? If yes then do it like this
Namespace:
using AjaxControlToolkit;
C#:
protected void ComboBox_OnSelectedIndexChanged(object sender, EventArgs e)
{
GridViewRow row = (sender as ComboBox).NamingContainer as GridViewRow;
ComboBox cb = (sender as ComboBox);
string item = cb.SelectedItem.Value;
DataSet ds = new DataSet();
// Code for searching the item description from SQL and hold it into DataTable or Dataset
//Set the values in TextBox
(row.FindControl("TxtName") as TextBox).Text = ds.Tables[0].Rows[0]["Name"].ToString();
}