I am almost happy with the following:
<ajax:Twitter ID="twtHome"
runat="server"
Mode="Profile"
ScreenName="TwitterID"
Width="325px"
Height="290px"
meta:resourceKey="twtHome"
IncludeReplies="False"
IncludeRetweets="False"
Count="4"
BackColor="White"
ForeColor="DimGray" >
<EmptyDataTemplate>
There are no matching tweets.
</EmptyDataTemplate>
<LayoutTemplate>
<div id="Div1" runat="server" class="ajax__twitter_header_custom">
<img src="images/twitter_bird.png" alt="" />
<h3 id="H1" runat="server"><asp:Literal ID="litFollowUs" runat="server" meta:resourceKey="litFollowUs" /></h3>
<h4 id="H2" runat="server"><asp:Literal ID="litNews" runat="server" meta:resourceKey="litNews" /></h4>
</div>
<ul id="Ul1" runat="server" class="ajax__twitter_itemlist_custom" style="margin:0px; background-color: White;">
<asp:PlaceHolder runat="server" ID="ItemPlaceholder"></asp:PlaceHolder>
</ul>
<div id="Div2" runat="server" class="ajax__twitter_footer_custom">
<img src="images/twitter_long.png" alt="" />
</div>
</LayoutTemplate>
</ajax:Twitter>
Except I don't know how to modify colors of item post dates and links but I try to live with defaults for the time being.