Here I have created sample that will help you out.
HTML
<div>
<cc1:ToolkitScriptManager runat="server">
</cc1:ToolkitScriptManager>
Select Name :<asp:DropDownList ID="ddlNames" runat="server" OnSelectedIndexChanged="SelectedEventChnged"
AutoPostBack="true">
<asp:ListItem Text="David" />
<asp:ListItem Text="Jhon" />
</asp:DropDownList>
<asp:LinkButton ID="lnkFake" runat="server" Style="display: none" />
<!-- ModalPopupExtender -->
<cc1:ModalPopupExtender ID="mp1" runat="server" PopupControlID="Panel1" TargetControlID="lnkFake"
CancelControlID="btnClose" BackgroundCssClass="modalBackground">
</cc1:ModalPopupExtender>
<asp:Panel ID="Panel1" runat="server" CssClass="modalPopup" align="center" Style="display: none">
This is an ASP.Net AJAX ModalPopupExtender Example<br />
Welcome :
<asp:Label ID="lblName" runat="server" />
<br />
<asp:Button ID="btnClose" runat="server" Text="Close" />
</asp:Panel>
</div>
Screenshot
