The only way is to hide the Footer Row on all pages except the last page as shown below
Database
Northwind
HTML
 <asp:GridView ID="gvProducts" runat="server" AutoGenerateColumns="false" AllowPaging="true"
            PageSize="10" ShowFooter="true" OnPageIndexChanging="gvProducts_OnPageIndexChanging" OnDataBound = "OnDataBound">
            <Columns>
                <asp:TemplateField HeaderText="ProductName">
                    <ItemTemplate>
                        <asp:Label ID="lblProductName" runat="server" Text='<%# Eval("ProductName") %>' />
                    </ItemTemplate>
                    <FooterTemplate>
                        <asp:TextBox ID="txtProductName" runat="server" />
                    </FooterTemplate>
                </asp:TemplateField>
                <asp:TemplateField HeaderText="QuantityPerUnit">
                    <ItemTemplate>
                        <asp:Label ID="lblQuantityPerUnit" runat="server" Text='<%# Eval("QuantityPerUnit") %>' />
                    </ItemTemplate>
                    <FooterTemplate>
                        <asp:TextBox ID="txtQuantityPerUnit" runat="server" />
                    </FooterTemplate>
                </asp:TemplateField>
                <asp:TemplateField HeaderText="UnitPrice">
                    <ItemTemplate>
                        <asp:Label ID="lblUnitPrice" runat="server" Text='<%# Eval("UnitPrice") %>' />
                    </ItemTemplate>
                    <FooterTemplate>
                        <asp:TextBox ID="txtUnitPrice" runat="server" />
                    </FooterTemplate>
                </asp:TemplateField>
                <asp:TemplateField HeaderText="UnitsInStock">
                    <ItemTemplate>
                        <asp:Label ID="lblUnitsInStock" runat="server" Text='<%# Eval("UnitsInStock") %>' />
                    </ItemTemplate>
                    <FooterTemplate>
                        <asp:TextBox ID="txtUnitsInStock" runat="server" />
                    </FooterTemplate>
                </asp:TemplateField>
            </Columns>
        </asp:GridView>
Namespaces
using System.Configuration;
using System.Data.SqlClient;
using System.Data;
Code
    protected void Page_Load(object sender, EventArgs e)
    {
        if (!this.IsPostBack)
        {
            PopulateProducts();
        }
    }
    protected void gvProducts_OnPageIndexChanging(object sender, GridViewPageEventArgs e)
    {
        this.gvProducts.PageIndex = e.NewPageIndex;
        this.PopulateProducts();
    }
    protected void OnDataBound(object sender, EventArgs e)
    {
        gvProducts.FooterRow.Visible = this.gvProducts.PageIndex == this.gvProducts.PageCount - 1;
    }
    private void PopulateProducts()
    {
        string constr = ConfigurationManager.ConnectionStrings["ConString"].ConnectionString;
        using (SqlConnection conn = new SqlConnection(constr))
        {
            using (SqlCommand cmd = new SqlCommand("SELECT [ProductName],[QuantityPerUnit],[UnitPrice],[UnitsInStock] FROM [Products]", conn))
            {
                using (SqlDataAdapter da = new SqlDataAdapter(cmd))
                {
                    DataSet ds = new DataSet();
                    da.Fill(ds);
                    this.gvProducts.DataSource = ds;
                    this.gvProducts.DataBind();
                }
            }
        }
    }