Hi Ilanocf,
Please refer below Sample.
HTML
<asp:ScriptManager runat="server" ID="ScriptManager1" />
<asp:UpdatePanel runat="server" ID="UpdatePanel1">
    <ContentTemplate>
        <asp:TextBox ID="Editor1" runat="server" Width="300" Height="200" />
        <br />
        <asp:Button Text="Save" runat="server" OnClick="OnSave" />
    </ContentTemplate>
</asp:UpdatePanel>
Namespaces
C#
using System.Data;
using System.Data.SqlClient;
using System.Configuration;
VB.Net
Imports System.Data
Imports System.Configuration
Imports System.Data.SqlClient
Code
C#
public bool RemoveLinhasVazias(string pTexto)
{
    string[] pDelimiters = new string[] { "\n", "\r", "\n\r" };
    string[] pLines = pTexto.Split(pDelimiters, StringSplitOptions.RemoveEmptyEntries);
    string pResult = string.Join(Environment.NewLine, pLines);
    pResult = StripHTML(pResult);
    if (string.IsNullOrEmpty(pResult.Trim()))
    {
        return true;
    }
    else
    {
        return false;
    }
}
public static string StripHTML(string input)
{
    return System.Text.RegularExpressions.Regex.Replace(input, "<.*?>", String.Empty);
}
protected void OnSave(object sender, EventArgs e)
{
    string pTexto;
    pTexto = Editor1.Text.Trim();
    if (RemoveLinhasVazias(pTexto))
    {
        ScriptManager.RegisterStartupScript(this, this.GetType(), "", "alert('Empty');", true);
    }
    else if (!RemoveLinhasVazias(pTexto))
    {
        string conString = ConfigurationManager.ConnectionStrings["constr"].ConnectionString;
        using (SqlConnection con = new SqlConnection(conString))
        {
            using (SqlCommand cmd = new SqlCommand("INSERT INTO HTMLContent (Content) VALUES (@content)", con))
            {
                cmd.Parameters.Add("@content", SqlDbType.NVarChar).Value = Editor1.Text;
                con.Open();
                cmd.ExecuteNonQuery();
                con.Close();
            }
        }
    }
}
VB.Net
Public Function RemoveLinhasVazias(ByVal pTexto As String) As Boolean
    Dim pDelimiters As String() = New String() {vbLf, vbCr, vbLf & vbCr}
    Dim pLines As String() = pTexto.Split(pDelimiters, StringSplitOptions.RemoveEmptyEntries)
    Dim pResult As String = String.Join(Environment.NewLine, pLines)
    pResult = StripHTML(pResult)
    If String.IsNullOrEmpty(pResult.Trim()) Then
        Return True
    Else
        Return False
    End If
End Function
Public Shared Function StripHTML(ByVal input As String) As String
    Return System.Text.RegularExpressions.Regex.Replace(input, "<.*?>", String.Empty)
End Function
Protected Sub OnSave(ByVal sender As Object, ByVal e As EventArgs)
    Dim pTexto As String
    pTexto = Editor1.Text.Trim()
    If RemoveLinhasVazias(pTexto) Then
        ScriptManager.RegisterStartupScript(Me, Me.GetType(), "", "alert('Empty');", True)
    ElseIf Not RemoveLinhasVazias(pTexto) Then
        Dim conString As String = ConfigurationManager.ConnectionStrings("constr").ConnectionString
        Using con As SqlConnection = New SqlConnection(conString)
            Using cmd As SqlCommand = New SqlCommand("INSERT INTO HTMLContent (Content) VALUES (@content)", con)
                cmd.Parameters.Add("@content", SqlDbType.NVarChar).Value = Editor1.Text
                con.Open()
                cmd.ExecuteNonQuery()
                con.Close()
            End Using
        End Using
    End If
End Sub
Screenshot
