@amAturCodr, try this code and make sure to modify condition based on your requirement.
protected void OnRowDataBound(object sender, GridViewRowEventArgs e)
{
    if (e.Row.RowType == DataControlRowType.DataRow)
    {
        TableCell cell = e.Row.Cells[1];
       // int ID= int.Parse(cell.Text);//for numbers we use this method to extract first digit
       string ID=  cell.Text;
       string firstdigit= ID.ToString().Substring(0,1); 
        if (firstdigit== "a")
        {
            cell.BackColor = Color.Red;
        }
      else   if (firstdigit== "A")
        {
            cell.BackColor = Color.Yellow;
        }
    
    }
}