Disable User click in Header and some specific Rows of GridView using jQuery in ASP.Net

Hi,

Here I have created sample that will help you out.

HTML

<div>
    <asp:ScriptManager ID="sm1" runat="server">
    </asp:ScriptManager>
    <script type="text/javascript" src="http://ajax.googleapis.com/ajax/libs/jquery/1.8.3/jquery.min.js"></script>
    <script type="text/javascript">
        $(function () {
            $('[id*=GridView1] tr td').click(function () {
                var cellIndex = $(this).index();
                if (cellIndex > 1) {
                    $find("mpe").show();
                } else {
                    $find("mpe").hide();
                }
                return false;
            });
        });
    </script>
    <asp:LinkButton ID="lnkDummy" runat="server"></asp:LinkButton>
    <cc1:ModalPopupExtender ID="ModalPopupExtender1" BehaviorID="mpe" runat="server"
        PopupControlID="pnlPopup" TargetControlID="lnkDummy" CancelControlID="btn" BackgroundCssClass="modalBackground">
    </cc1:ModalPopupExtender>
    <asp:Panel ID="pnlPopup" runat="server" CssClass="modalPopup" GroupingText="Testing"
        Style="display: none">
        <asp:Label ID="label1" runat="server">This is a label from ModalPopupExtender.</asp:Label>
        <br />
        <button id="btn" runat="server">
            Cancel</button>
    </asp:Panel>
    <asp:GridView ID="GridView1" runat="server" AutoGenerateColumns="false">
        <Columns>
            <asp:TemplateField HeaderText="Id">
                <ItemTemplate>
                    <asp:Label ID="lblId" runat="server" Text='<%# Eval("Id") %>' />
                </ItemTemplate>
            </asp:TemplateField>
            <asp:TemplateField HeaderText="Reg. Id">
                <ItemTemplate>
                    <asp:Label ID="lblRegId" runat="server" Text='<%# Eval("RegId") %>' />
                </ItemTemplate>
            </asp:TemplateField>
            <asp:TemplateField HeaderText="FirstName">
                <ItemTemplate>
                    <asp:Label ID="lblFirstName" runat="server" Text='<%# Eval("FirstName") %>' />
                </ItemTemplate>
            </asp:TemplateField>
            <asp:TemplateField HeaderText="LastName">
                <ItemTemplate>
                    <asp:Label ID="lblLastName" runat="server" Text='<%# Eval("LastName") %>' />
                </ItemTemplate>
            </asp:TemplateField>
        </Columns>
    </asp:GridView>
</div>

C#

protected void Page_Load(object sender, EventArgs e)
{
    GridView1.DataSource = new List<Item>
    {
        new Item {Id =1,RegId=111 ,FirstName = "David", LastName = "Morkel"},
        new Item {Id =2,RegId=222,FirstName = "Kevin", LastName = "George"},
        new Item {Id =3,RegId=333,FirstName = "Jhon", LastName = "Resig"},
        new Item {Id =4,RegId=444,FirstName = "Peter", LastName = "Morkel"}
    };
    GridView1.DataBind();
}

public class Item
{
    public int Id { get; set; }
    public int RegId { get; set; }
    public string FirstName { get; set; }
    public string LastName { get; set; }
}

Screenshot