This way
 
protected void UploadFile(object sender, EventArgs e)
    {
        using (FilesEntities entities = new FilesEntities())
        {
            tblFile file = new tblFile
            {
                Name = Path.GetFileName(fuUploadFile.PostedFile.FileName),
                ContentType = fuUploadFile.PostedFile.ContentType,
                Data = fuUploadFile.FileBytes,
            };
            entities.AddTotblFiles(file);
            entities.SaveChanges();
        }
    }