In this article I will explain with an example, how to resize image without loosing its image quality (quality loss) in ASP.Net.
HTML Markup
The following HTML Markup consists of 2 ASP.Net Image Controls of which one displays the original image while other displays the Thumbnail of the original image. Also there is an ASP.Net Button control which generates the Thumbnail.
<form id="form1" runat="server">
<asp:Image ID="Image1" runat="server" ImageUrl = "~/Jellyfish.jpg" Height = "400px" Width = "400px"/>
<br />
<asp:Button ID="btnGenerate" OnClick = "GenerateThumbnail" runat="server" Text="Generate Thumbnail" />
<hr />
<asp:Image ID="Image2" runat="server" Visible = "false"/>
You will need to import the following namespace.

using System.IO;
using System.Drawing;
using System.Drawing.Imaging;
Imports System.IO
Imports System.Drawing
Imports System.Drawing.Imaging
Resizing Image and Generating Thumbnail
Below is the code that dynamically resizes the picture and generates the Thumbnail and also displays it in Image Control.

protected void GenerateThumbnail(object sender, EventArgs e)
    string path = Server.MapPath("~/Jellyfish.jpg");
    System.Drawing.Image image = System.Drawing.Image.FromFile(path);
    using (System.Drawing.Image thumbnail = image.GetThumbnailImage(100, 100, new System.Drawing.Image.GetThumbnailImageAbort(ThumbnailCallback), IntPtr.Zero))
        using (MemoryStream memoryStream = new MemoryStream())
            thumbnail.Save(memoryStream, ImageFormat.Png);
            Byte[] bytes = new Byte[memoryStream.Length];
            memoryStream.Position = 0;
            memoryStream.Read(bytes, 0, (int)bytes.Length);
            string base64String = Convert.ToBase64String(bytes, 0, bytes.Length);
            Image2.ImageUrl = "data:image/png;base64," + base64String;
            Image2.Visible = true;
public bool ThumbnailCallback()
    return false;
Protected Sub GenerateThumbnail(sender As Object, e As EventArgs)
    Dim path As String = Server.MapPath("~/Jellyfish.jpg")
    Dim image As System.Drawing.Image = System.Drawing.Image.FromFile(path)
    Using thumbnail As System.Drawing.Image = image.GetThumbnailImage(100, 100, New System.Drawing.Image.GetThumbnailImageAbort(AddressOf ThumbnailCallback), IntPtr.Zero)
        Using memoryStream As New MemoryStream()
            thumbnail.Save(memoryStream, ImageFormat.Png)
            Dim bytes As [Byte]() = New [Byte](memoryStream.Length - 1) {}
            memoryStream.Position = 0
           memoryStream.Read(bytes, 0, CInt(bytes.Length))
            Dim base64String As String = Convert.ToBase64String(bytes, 0, bytes.Length)
            Image2.ImageUrl = "data:image/png;base64," & base64String
            Image2.Visible = True
        End Using
    End Using
End Sub
Public Function ThumbnailCallback() As Boolean
    Return False
End Function